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KMID : 0377519980230030129
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Chung-Ang Journal of Medicine
1998 Volume.23 No. 3 p.129 ~ p.137
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Immunohistochemical analysis of overexpression of p53 oncoprotein in hepatocellular carcinoma
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Yoo Jae-Hyung
Park Eon-Sub
Kim Mi-Kyung
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Abstract
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To study comparative analysis of p53 overexpression and clinicopathologic data of 85 hepatocellular carcinomas, immunohistochemical study using avidin-biotin complex method was performed. The results were as follows ; 1. The age distribution was 30-80 years old, and sex ratio was 76 male : 9 female. Serologically number of HBsAg positive and negative group were 51 and 34, respectively. Edmonson and Steiner’s histologic grading of examined hepatocellular carcinoma cases consisted of grade Ⅱ of 48 cases and grade Ⅲ of 37 cases 2. The frequency of p53 immunoreactivity in 85 hepatocellular carcinomas was 52.9%. 3. The frequency of p53 overexpression in HBsAg positive and HBsAg negative group was 58.8% and 44.1%, respectively. The frequency of strong p53 immunoreactivity was 25.4%(13/51) in HBsAg positive group and 5.9% in HBsAg negative group. Although p53 expression of HBsAg positive hepatocellular carcinoma has an increasing tendency than that of HBsAg negative hephtocellular carcinoma. 4. The frequency of p53 overexpression in grade Ⅱ and Ⅲ hepatocellular carcinomas was 33.3% and 78.3%, respectively. The frequency of strong p53 immunoreactivity was 2.1% in grade Ⅱ and 37.8% in grade Ⅲ. Therefore, correlation of p53 overexpression and grading of hepatocellular carcinoma was statistically significant. 5. The correlation of p53 overexpression and age with or without HBsAg was statistically significant. The frequency of p53 expression by age was 62.5% in thirties, 41.2% in forties, 51.8% in sixties and 57.5% in sixties-eighties. 6. It is therefore, suggested that p53 overexpression of hepatocellular carcinoma depended upon grading of tumor cells and age(with/without HBsAg).
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KEYWORD
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p53, HBsAg, age, hepatocellular carcinoma
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